Ingredients
What is PDRN in skincare? A clear guide
PDRN is purified DNA from salmon, used in Korean skincare for skin that looks hydrated, smooth and bouncy. Here is what it is, where it comes from and how to use it.
In short
PDRN (polydeoxyribonucleotide) is a purified fragment of DNA, usually from salmon. In skincare it is listed as sodium DNA and is used to help skin look and feel more hydrated, smoother and bouncier. It is generally gentle and works well alongside other skincare.
Key takeaways
- PDRN is purified DNA from salmon, listed on labels as sodium DNA.
- In skincare it helps skin look and feel hydrated, smooth and bouncy.
- Clinics use injectable PDRN; skincare applies it to the surface of the skin.
- It is generally gentle, but it is not vegan and not for fish allergies.
What is PDRN?
PDRN stands for polydeoxyribonucleotide. It is a chain of nucleotides, the small building blocks that DNA is made of, purified into short fragments that skincare can use.
On an ingredient list you will usually find it as sodium DNA. That is the name used on the KAHI Multi Balm and Eye Balm, alongside collagen and plant oils.
PDRN (polydeoxyribonucleotide): short, purified fragments of DNA, usually from salmon. Listed on cosmetic labels as sodium DNA.
Where does PDRN in skincare come from?
Most PDRN comes from salmon, as a by-product of the fishing industry. The DNA is purified to remove proteins and fats, leaving clean DNA fragments of a size that suits skincare formulas.
Because it comes from fish, skincare with salmon PDRN is not vegan. KAHI's balms also contain salmon collagen for the same reason.
What does PDRN do for skin?
PDRN first became known in Korean and Italian clinics, where injectable forms have been studied by doctors for years.1 Skincare uses it differently: applied to the surface, it is there for how skin looks and feels.
- Helps skin look and feel more hydrated
- Helps skin feel softer and look smoother
- Helps fine lines look less visible
- Helps skin look bouncier and more rested
+410%
Skin hydration measured straight after one application of the KAHI Multi Balm, which combines salmon PDRN, collagen and plant oils.2 Read the study
PDRN vs hyaluronic acid vs peptides
These three are often mentioned together. They do different jobs, which is why many formulas combine them.
| Ingredient | What it is | What it does for skin | Texture and feel | Best for |
|---|---|---|---|---|
| Salmon PDRN | Purified DNA fragments | Helps skin look hydrated, smooth and bouncy | Usually in balms, serums and creams | Dry, tired-looking or mature skin |
| Hyaluronic acid | A sugar that holds water | Draws water into the surface for instant plumpness | Light, watery gels and serums | All skin types, especially dehydrated skin |
| Peptides | Short chains of amino acids | Help skin look firmer and smoother over time | Serums, creams and eye products | Fine lines and loss of firmness |
Is PDRN safe for sensitive skin?
PDRN is generally gentle and well tolerated in skincare. In both studies of the KAHI Multi Balm, no participants had a skin reaction.2, 3
Good to know: as with any new product, try it on a small patch of skin first, and stop using it if irritation occurs. Salmon PDRN comes from fish, so if you have a fish allergy, check with your GP or pharmacist before use.
How do I use a PDRN balm stick?
A balm stick is the easiest way to use PDRN on the go. There is nothing to measure and no need to wash your hands.
- Twist Turn up a few millimetres of balm.
- Glide Sweep it over the eye area, smile lines, lips and neck as the last step of your routine.
- Tap Over make-up, tap it on gently rather than dragging, for a midday refresh.
Step by step, with where it goes in your routine: how to use a multi balm stick.
Face, eyes, smile lines, lips and neck
Frequently asked questions
Is PDRN vegan?
No. Salmon PDRN comes from fish, so skincare that contains it is not vegan. KAHI's balms also contain salmon collagen. They are cruelty-free.
Can I use PDRN with retinol or vitamin C?
Yes. PDRN is generally easy to combine with other skincare, including retinol and vitamin C. If your skin feels sensitive, use them at different times of day.
Can I use a PDRN balm around my eyes?
Yes, if the formula is suitable for the eye area. The KAHI Multi Balm and Eye Balm were both tested around the eyes. Glide gently along the outer corners and under the eyes, keeping the balm out of the eyes themselves.
How often can I use a PDRN balm stick?
As often as your skin feels dry. In the KAHI Multi Balm 4-week study, women used it twice a day, and you can reapply over make-up during the day.
Is PDRN skincare the same as a salmon DNA facial?
No. Salmon DNA facials are clinic treatments with injectable PDRN, carried out by medical professionals. Skincare uses PDRN on the surface of the skin, for how it looks and feels.
Sources and references
- Pharmacological activity and clinical use of PDRN. Squadrito F. et al., Frontiers in Pharmacology, 2017.
- KAHI Multi Balm single-application study, report ASC-26-E145-1 (23 women aged 51–69). Ace Skin Clinical Research Institute, Seoul, 2026.
- KAHI Multi Balm 4-week study, report ASC-26-E145-2 (20 women aged 51–69). Ace Skin Clinical Research Institute, Seoul, 2026.
- CosIng database of cosmetic ingredients: Sodium DNA. European Commission.
Last reviewed 30 September 2026. This article is for general information and is not medical advice. Report an issue with this article
